Diablo 4 Season 9 Farming Guide: Get Mythics, Ancestral Uniques & Runes Fast

By Ansley Fri Jul 11 2025 07:02:33 GMT+0000 (Coordinated Universal Time)

Season 9 of Diablo 4 has brought in some wild loot mechanics, and if you’re chasing mythic uniques, ancestral items, or legendary runes, here’s what you need to know. Skip the grind, maximize returns, and avoid the traps.

🔥 1. Nightmare Dungeon Escalations – Loot Central

Why it matters:
Nightmare dungeon escalations now drop crazy amounts of loot—we’re talking multiple Greater Ancestral items and up to 12 uniques from Astaroth on Torment IV.

What to do:

Pro tip: Each escalation can net you 6,000–8,000 Obducite, with Strongrooms alone being worth it just for the bulk Ancestral Legendaries.

🧨 2. Infernal Hordes – Best for Reputation and Runes

Why it matters:
If you want reputations fast, skip whispers and farm elites.

What to do:

Pro tip: Save your Aether to buy Greater Archetype Caches—each gives a Greater Ancestral item and a class-specific Ancestral Unique.

🧪 3. Obols & Vendors – Still Good With Buffs

Why it matters:
The Urn of Curiosities gives you a 20% bonus item chance from Obol gambles.

What to do:

🏛 4. Undercity Tributes – Legendary Runes & Ancestral Gear

What works:

Where to get tributes:

💀 5. Lair Bosses – Where the Mythics Drop

Here’s the hard truth:
To get Mythic Uniques and top-tier Ancestrals, you need Betrayer’s Husks. These drop from the rare Ambush Belial, which spawns maybe once every 10 kills.

So what’s the move?

Alternative:
Grind Belial manually if you enjoy pain and RNG hell.

⚒️ 6. Smithing Caches – Avoid the Trap

Why you should skip them:

Final Thoughts

This season makes loot wildly accessible—if you know where to look. Skip the outdated grind loops. Stick to:

Want the best gear? Plan your runs. Respect your time.